Monocytic leukaemia

Description

Juvenile Myelomonocytic Leukemia: A myelodysplastic/myeloproliferative neoplasm of childhood that is characterized by proliferation principally of the granulocytic and monocytic lineages. Myelomonocytic proliferation is seen in the bone marrow and the blood. The leukemic cells may infiltrate any tissue, however liver, spleen, lymph nodes, skin, and respiratory tract are the most common sites of involvement. (WHO, 2001)

Data source
FinnGen phenocode CD2_MONOCYTIC_LEUKAEMIA
Hospital Discharge registry ICD-10: C93
Cause of Death registry ICD-10: C93
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 0050458
GWAS catalog 1000309
MESH D054429
SNOMED CT 445227008

Key figures

Sex All Female Male
Number of individuals 24 9 15
Unadjusted prevalence (%) 0.02 0.01 0.03
Mean age at first event (years) 66.39 64.39 67.58
Median number of events / individual 1 2 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 45.83 66.67 33.33
Case fatality at 5-years (%) 41.67 44.44 40.0

Associations