Disorders of optic nerve, not elsewhere classified

Description

anterior ischemic optic neuropathy: Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135)

Data source
FinnGen phenocode H7_OPTNERVNAS
Hospital Discharge registry ICD-10: H470, ICD-8: 37799
Cause of Death registry ICD-10: H470, ICD-8: 37799
Level in the ICD-hierarchy 4
First defined in version DF2
Ontology
DOID 12010
GWAS catalog 1000809
MESH D018917
SNOMED CT 404659001

Key figures

Sex All Female Male
Number of individuals 136 65 71
Unadjusted prevalence (%) 0.1 0.09 0.12
Mean age at first event (years) 59.27 58.26 60.18
Median number of events / individual 1 1 2

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 35.29 32.31 38.03
Case fatality at 5-years (%) 4.41 4.62 4.23

Associations