Cholangitis (primary sclerosing, PSC)

Description

sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

Data source
FinnGen phenocode K11_CHOLANGI
Hospital Discharge registry ICD-10: K830, ICD-8: 5750[4-5]
Cause of Death registry ICD-10: K830, ICD-8: 5750[4-5]
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 14268
GWAS catalog 0004268
SNOMED CT 235917005

Key figures

Sex All Female Male
Number of individuals 386 198 188
Unadjusted prevalence (%) 0.29 0.26 0.33
Mean age at first event (years) 59.24 57.42 61.15
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 34.97 32.32 37.77
Case fatality at 5-years (%) 15.28 11.62 19.15

Associations