Crohn disease

Description

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Data source
FinnGen phenocode K11_CROHN
Hospital Discharge registry ICD-10: K50, ICD-9: 555, ICD-8: 5630
Cause of Death registry ICD-10: K50, ICD-9: 555, ICD-8: 5630
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 8778
GWAS catalog 0000384
SNOMED CT 7620006

Key figures

Sex All Female Male
Number of individuals 976 557 419
Unadjusted prevalence (%) 0.74 0.74 0.73
Mean age at first event (years) 45.24 43.68 47.3
Median number of events / individual 5 5 4

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 61.68 62.84 60.14
Case fatality at 5-years (%) 4.0 3.05 5.25

Associations