Disorders of skin appendages

Description

Yellow Nail Syndrome: Yellow nail syndrome (YNS) is a very rare syndromic disorder characterized by the variable triad of characteristic yellow nails, chronic respiratory manifestations, and primary lymphedema.

Data source
FinnGen phenocode L12_DISORDSKINAPPENDIX
Include L12_NAILDIS, L12_ALOPECAREATA, L12_ALOPECANDRO, L12_HAIRLOSSNONSCAR, L12_HAIRLOSSSCAR, L12_HAIRLOSSNAS, L12_HAIRCOLOUR, L12_HYPERTRICHOSIS, L12_ACNE, L12_ROSACEA, L12_FOLLICULARCYST, L12_FOLICULAROTH, L12_ECCRINESWEAT, L12_APOCRINESWEAT
Level in the ICD-hierarchy 2
First defined in version DF2
Ontology
DOID 0050468
GWAS catalog 1001452
MESH D056684
SNOMED CT 400211001

Key figures

Sex All Female Male
Number of individuals 4422 2598 1824
Unadjusted prevalence (%) 3.34 3.46 3.18
Mean age at first event (years) 45.12 45.51 44.58
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 29.38 31.95 25.71
Case fatality at 5-years (%) 1.42 0.81 2.3

Associations