Dorsopathies

Description

discitis: Inflammation of an intervertebral disc or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.

Data source
FinnGen phenocode M13_DORSOPATHY
Hospital Discharge registry ICD-10: M51/M50/M53/M54
Cause of Death registry ICD-10: M51/M53/M54/M50
Include M13_DEFORMDORSO, M13_SPONDYLOPATHY, M13_CERVICDISC, M13_INTERVERTEB, M13_DORSOPATHYOTH, M13_DORSALGIA, M13_ENTESOPATHYLOW
Level in the ICD-hierarchy 2
First defined in version DF2
Ontology
DOID 10986
GWAS catalog 1000900
MESH D015299
SNOMED CT 2304001

Key figures

Sex All Female Male
Number of individuals 32547 19042 13505
Unadjusted prevalence (%) 24.55 25.34 23.52
Mean age at first event (years) 49.44 49.36 49.56
Median number of events / individual 2 2 2

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 48.44 49.63 46.75
Case fatality at 5-years (%) 2.26 1.8 2.91

Associations