Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium

Description

HELLP syndrome: HELLP syndrome is a life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: H emolysis, E levated L iver enzyme levels, and L ow P latelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia . If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby.The main treatment is to deliver the baby as soon as possible, even if premature. Treatment may also includemedications needed for the mother or baby, and blood transfusion for severe bleeding problems.

Data source
FinnGen phenocode O15_OEDEM_PROTUR_HYPERT
Sex specific endpoint 2
Include O15_EXIST_HYPERT_COMPLIC, O15_PREECLAMPS_CHRONIC_HYPERT, O15_GESTAT_OEDEM_PREINUR, O15_GESTAT_HYPERT, O15_PREECLAMPS, O15_ECLAMPSIA, O15_MATERN_HYPERT_UNS
Level in the ICD-hierarchy 2
First defined in version DF3
Ontology
DOID 13133
GWAS catalog 0007297
MESH D017359

Key figures

Sex All Female Male
Number of individuals 2850 2850 N/A
Unadjusted prevalence (%) 2.15 3.79 N/A
Mean age at first event (years) 30.84 30.84 N/A
Median number of events / individual 1 1 N/A

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 10.88 10.88 N/A
Case fatality at 5-years (%) 0.0 0.0 N/A

Associations