Tuberculosis

Description

obsolete_tuberculosis: ['A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. --2004', 'Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.']

Data source
FinnGen phenocode TUBERCULOSIS
Hospital Discharge registry ICD-10: A19/A16/A15/B909, ICD-9: 012/011/018, ICD-8: 01[1-2]|018
Cause of Death registry ICD-10: A15/B909/A19/A16, ICD-9: 012/011/018, ICD-8: 01[1-2]|018
First defined in version DF2
Ontology
DOID 399
GWAS catalog 0000774

Key figures

Sex All Female Male
Number of individuals 644 318 326
Unadjusted prevalence (%) 0.49 0.42 0.57
Mean age at first event (years) 47.7 45.79 49.56
Median number of events / individual 1 1 2

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 41.46 38.68 44.17
Case fatality at 5-years (%) 8.85 5.97 11.66

Associations