Human immunodeficiency virus [HIV] disease

Description

AIDS: A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood.

Data source
FinnGen phenocode AB1_HIV
Hospital Discharge registry ICD-10: B24/B23/B20/B21/B22, ICD-9: 0788C/0788A/0788B
Cause of Death registry ICD-10: B23/B22/B20/B21/B24, ICD-9: 0788C/0788A/0788B
Level in the ICD-hierarchy 2
First defined in version DF2
Ontology
DOID 635
GWAS catalog 0000765
MESH D000163
SNOMED CT 62479008

Key figures

Sex All Female Male
Number of individuals 242 51 191
Unadjusted prevalence (%) 0.18 0.07 0.33
Mean age at first event (years) 40.94 41.42 40.8
Median number of events / individual 31 19 32

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 92.15 78.43 95.81
Case fatality at 5-years (%) 0.41 0.0 0.52

Associations