Non-follicular lymphoma


neoplasm of mature B-cells: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Data source
Hospital Discharge registry ICD-10: C83
Cause of Death registry ICD-10: C83
Level in the ICD-hierarchy 3
First defined in version DF2
DOID 0050873, 706, 707
GWAS catalog 0000096
SNOMED CT 269476000

Key figures

Sex All Female Male
Number of individuals 611 267 344
Unadjusted prevalence (%) 0.46 0.36 0.6
Mean age at first event (years) 63.45 62.86 63.91
Median number of events / individual 6 6 5

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 70.38 73.03 68.31
Case fatality at 5-years (%) 16.53 13.86 18.6