Cryoglobulinemia

Description

cryoglobulinemia: Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease ); and/or cancers of the blood or immune system . Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause.

Data source
FinnGen phenocode D3_CRYOGLOBU
Hospital Discharge registry ICD-10: D891, ICD-9: 2732A, ICD-8: 2754
Cause of Death registry ICD-10: D891, ICD-9: 2732A, ICD-8: 2754
Level in the ICD-hierarchy 4
First defined in version DF2
Ontology
DOID 2917
GWAS catalog 0005846
MESH D003449
SNOMED CT 30911005

Key figures

Sex All Female Male
Number of individuals 9 N/A N/A
Unadjusted prevalence (%) 0.01 N/A N/A
Mean age at first event (years) 50.06 N/A N/A
Median number of events / individual 1 N/A N/A

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 11.11 N/A N/A
Case fatality at 5-years (%) 11.11 N/A N/A

Associations