Other disorders of white blood cells
Description
Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.
Data source
| FinnGen phenocode | D3_OTHERWHITECELL |
| Hospital Discharge registry | ICD-10: D72 |
| Cause of Death registry | ICD-10: D72 |
| Include | D3_LEUKOANOMALIAGEN, D3_EOSINOPHILIA, D3_WHITEBLOODCELLNAS |
| Level in the ICD-hierarchy | 3 |
| First defined in version | DF2 |
Key figures
| Sex | All | Female | Male |
| Number of individuals | 362 | 189 | 173 |
| Unadjusted prevalence (%) | 0.27 | 0.25 | 0.3 |
| Mean age at first event (years) | 54.83 | 53.12 | 56.7 |
| Median number of events / individual | 1 | 1 | 1 |
Clinical metrics
| Sex | All | Female | Male |
| Recurrence within 6 months (%) | 24.59 | 23.81 | 25.43 |
| Case fatality at 5-years (%) | 7.18 | 4.76 | 9.83 |