myxedema: A condition characterized by severe hypothyroidism that is caused by autoimmune thyroid gland disorders, surgical reduction of thyroid tissue, radiation exposure, and viral infections. Signs and symptoms include generalized fatigue, lethargy, increased body weight, pale, edematous and thickened skin, low blood pressure, constipation and cold intolerance.

Data source
FinnGen phenocode E4_HYTHYNAS
Hospital Discharge registry ICD-10: E038/E039, ICD-8: 244
Hospital Discharge registry: exclude ICD-9 2448A|2448B
Hospital Discharge registry: exclude ICD-8 24409
Cause of Death registry ICD-10: E038/E039, ICD-8: 244
Cause of Death registry: exclude ICD-9 2448A|2448B
KELA reimboursements codes 104
KELA reimbursements ICD-10: E03
Medicine purchases: ATC codes H03A
Level in the ICD-hierarchy 3
First defined in version DF2
DOID 11634
GWAS catalog 1001055
MESH D009230
SNOMED CT 43153006

Key figures

Sex All Female Male
Number of individuals 16722 13510 3212
Unadjusted prevalence (%) 12.61 17.98 5.59
Mean age at first event (years) 53.21 52.22 57.35
Median number of events / individual 26 27 21

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 92.52 93.08 90.19
Case fatality at 5-years (%) 2.35 1.59 5.54