Lactose intolerance


lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.

Data source
FinnGen phenocode E4_LACTOSEINT
Hospital Discharge registry ICD-10: E73
Cause of Death registry ICD-10: E73
Level in the ICD-hierarchy 3
First defined in version DF2
DOID 10604
GWAS catalog 1000062
SNOMED CT 267425008

Key figures

Sex All Female Male
Number of individuals 262 175 87
Unadjusted prevalence (%) 0.2 0.23 0.15
Mean age at first event (years) 40.54 39.61 42.42
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 11.83 12.0 11.49
Case fatality at 5-years (%) 1.91 1.71 2.3