Disorder of thyroid, unspecified


euthyroid sick syndrome: Conditions of abnormal THYROID HORMONES release in patients with apparently normal THYROID GLAND during severe systemic illness, physical TRAUMA, and psychiatric disturbances. It can be caused by the loss of endogenous hypothalamic input or by exogenous drug effects. The most common abnormality results in low T3 THYROID HORMONE with progressive decrease in THYROXINE; (T4) and TSH. Elevated T4 with normal T3 may be seen in diseases in which THYROXINE-BINDING GLOBULIN synthesis and release are increased.

Data source
FinnGen phenocode E4_THYROIDNASOTH
Hospital Discharge registry ICD-10: E079, ICD-8: 24599
Cause of Death registry ICD-10: E079, ICD-8: 24599
Level in the ICD-hierarchy 3
First defined in version DF2
DOID 2856
GWAS catalog 1000931
MESH D005067
SNOMED CT 237542005

Key figures

Sex All Female Male
Number of individuals 109 85 24
Unadjusted prevalence (%) 0.08 0.11 0.04
Mean age at first event (years) 43.24 43.37 42.79
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 20.18 23.53 8.33
Case fatality at 5-years (%) 0.92 1.18 0.0