Thyrotoxicosis with diffuse goitr


Graves disease: Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland ( hyperthyroidism ).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy , antithyroid drugs, and/or thyroid surgery.

Data source
FinnGen phenocode E4_THYTOXGOITDIF
Hospital Discharge registry ICD-10: E050, ICD-8: 2420
Cause of Death registry ICD-10: E050, ICD-8: 2420
Level in the ICD-hierarchy 3
First defined in version DF2
DOID 10719, 12361
GWAS catalog 0004237
MESH D006111
SNOMED CT 353295004

Key figures

Sex All Female Male
Number of individuals 1216 1015 201
Unadjusted prevalence (%) 0.92 1.35 0.35
Mean age at first event (years) 48.84 48.46 50.74
Median number of events / individual 3 3 3

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 66.86 66.5 68.66
Case fatality at 5-years (%) 1.73 1.67 1.99