Other degenarative diseases of the basal ganglia

Description

obsolete_supranuclear palsy, progressive: ['A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei (MeSH).']

Data source
FinnGen phenocode G6_BASDEGENOTH
Hospital Discharge registry ICD-10: G23
Cause of Death registry ICD-10: G23
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 678
GWAS catalog 0002512

Key figures

Sex All Female Male
Number of individuals 68 27 41
Unadjusted prevalence (%) 0.05 0.04 0.07
Mean age at first event (years) 64.37 61.48 66.27
Median number of events / individual 2 3 2

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 51.47 51.85 51.22
Case fatality at 5-years (%) 23.53 22.22 24.39

Associations