Other demyelinating diseases of the central nervous system


central pontine myelinolysis: A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)

Data source
FinnGen phenocode G6_OTHDEMYEL
Hospital Discharge registry ICD-10: G37, ICD-8: 3410[2-9]
Cause of Death registry ICD-10: G37, ICD-8: 3410[2-9]
Level in the ICD-hierarchy 3
First defined in version DF2
DOID 636
GWAS catalog 1000857
MESH D017590
SNOMED CT 6807001

Key figures

Sex All Female Male
Number of individuals 257 182 75
Unadjusted prevalence (%) 0.19 0.24 0.13
Mean age at first event (years) 42.06 40.69 45.37
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 34.63 37.36 28.0
Case fatality at 5-years (%) 2.72 1.1 6.67