Disorders of lacrimal system

Description

dry eye syndrome: Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.

Data source
FinnGen phenocode H7_LACRIMALSYSTEM
Hospital Discharge registry ICD-10: H04
Include H7_DACRYOADENITIS, H7_LACRIGLAND, H7_EPIPHORA, H7_LACRIMINFLAMACU, H7_LACRIMINFLAMCHRON, H7_STENOLACRI, H7_LACRIPAS, H7_LACRINAS
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 10140
GWAS catalog 1000906
MESH D015352
SNOMED CT 46152009

Key figures

Sex All Female Male
Number of individuals 3604 2613 991
Unadjusted prevalence (%) 2.72 3.48 1.73
Mean age at first event (years) 56.05 55.44 57.68
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 24.78 25.79 22.1
Case fatality at 5-years (%) 3.05 2.41 4.74

Associations