Disorders of ocular muscles, binocular movement, accommodation and refraction

Description

trochlear nerve disease: Diseases of the fourth cranial (trochlear) nerve or its nucleus in the midbrain. The nerve crosses as it exits the midbrain dorsally and may be injured along its course through the intracranial space, cavernous sinus, superior orbital fissure, or orbit. Clinical manifestations include weakness of the superior oblique muscle which causes vertical DIPLOPIA that is maximal when the affected eye is adducted and directed inferiorly. Head tilt may be seen as a compensatory mechanism for diplopia and rotation of the visual axis. Common etiologies include CRANIOCEREBRAL TRAUMA and INFRATENTORIAL NEOPLASMS.

Data source
FinnGen phenocode H7_OCUMUSCLE
Hospital Discharge registry ICD-10: H51/H52/H50/H49
Cause of Death registry ICD-10: H49/H52/H51/H50
Include H7_PARASTRAB, H7_STRABOTH, H7_BINOCUMOVOTH, H7_REFRAACCOMMODIS
Level in the ICD-hierarchy 2
First defined in version DF2
Ontology
DOID 13864
GWAS catalog 1001220
MESH D020432

Key figures

Sex All Female Male
Number of individuals 4350 2730 1620
Unadjusted prevalence (%) 3.28 3.63 2.82
Mean age at first event (years) 37.77 36.45 39.99
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 24.87 24.58 25.37
Case fatality at 5-years (%) 1.93 1.5 2.65

Associations