Disorders of optic nerve and visual pathways

Description

Foster-Kennedy syndrome: Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.

Data source
FinnGen phenocode H7_OPTNERVE
Hospital Discharge registry ICD-10: H46/H47
Cause of Death registry ICD-10: H46/H47
Include H7_OPTNEURITIS, H7_OPTNEUROTH, H7_RETROBULBNEURINOTH, H7_OPTNERVPATHINOTH
Level in the ICD-hierarchy 2
First defined in version DF2
Ontology
DOID 14555
GWAS catalog 1001330
SNOMED CT 87764000

Key figures

Sex All Female Male
Number of individuals 726 466 260
Unadjusted prevalence (%) 0.55 0.62 0.45
Mean age at first event (years) 46.27 43.96 50.41
Median number of events / individual 2 2 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 39.53 40.56 37.69
Case fatality at 5-years (%) 3.17 2.58 4.23

Associations