Conduction disorders


Wolff-Parkinson-White Syndrome: A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.

Data source
FinnGen phenocode I9_CONDUCTIO
Hospital Discharge registry ICD-10: I44/I45, ICD-9: 426
Cause of Death registry ICD-10: I45/I44, ICD-9: 426
Level in the ICD-hierarchy 3
First defined in version DF2
DOID 384
GWAS catalog 1001450
SNOMED CT 17869006

Key figures

Sex All Female Male
Number of individuals 2565 1141 1424
Unadjusted prevalence (%) 1.94 1.52 2.48
Mean age at first event (years) 64.44 62.76 65.8
Median number of events / individual 1 1 2

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 35.36 31.99 38.06
Case fatality at 5-years (%) 11.62 10.69 12.36