Myocarditis

Description

myocarditis: Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus , Wegener's granulomatosis , giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and, rarely, a heart transplant may be needed if the heart muscle becomes weak. [ https://rarediseases.info.nih.gov/diseases/7137/myocarditis ]

Data source
FinnGen phenocode I9_MYOCARD
Hospital Discharge registry ICD-10: I41/I40, ICD-9: 422, ICD-8: 0742|422
Cause of Death registry ICD-10: I41/I40, ICD-9: 422, ICD-8: 0742|422
Level in the ICD-hierarchy 4
First defined in version DF2
Ontology
DOID 820
GWAS catalog 0009609
MESH D009205
SNOMED CT 50920009

Key figures

Sex All Female Male
Number of individuals 487 192 295
Unadjusted prevalence (%) 0.37 0.26 0.51
Mean age at first event (years) 43.65 48.58 40.45
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 21.77 21.88 21.69
Case fatality at 5-years (%) 5.54 4.17 6.44

Associations