Lung diseases due to external agents

Description

extrinsic allergic alveolitis: An inflammatory interstitial lung disease caused by hypersensitivity reaction to inhalation or ingestion of antigens. The antigens are usually related to the patient's occupation. It can present as an acute illness with flu-like symptoms, subacute with repeated episodes of pneumonia, or chronic with dyspnea and productive cough. The majority of patients recover following the cessation of the exposure to the antigen that causes the disease. Chronic exposure may eventually progress to interstitial lung fibrosis.

Data source
FinnGen phenocode J10_EXTERLUNG
Include J10_COALPNEUMOC, J10_ASBESTPNEUMOC, J10_SILICAPNEUMOC, J10_INORGPNEUMOC, J10_NASPNEUMOC, J10_TUBERCPNEUMOC, J10_AIRWDISDUST, J10_HYPERSPNEUMONI, J10_CHEMGASRESP, J10_PNEUMONISOLLIQ, J10_RESPCONDEXT
Level in the ICD-hierarchy 2
First defined in version DF2
Ontology
DOID 841
GWAS catalog 1001321
MESH D000542

Key figures

Sex All Female Male
Number of individuals 1088 423 665
Unadjusted prevalence (%) 0.82 0.56 1.16
Mean age at first event (years) 59.94 57.04 61.78
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 22.89 24.35 21.95
Case fatality at 5-years (%) 28.77 23.64 32.03

Associations