Erythema multiforme

Description

erythema multiforme: Erythema multiforme (EM) refers to a group ofhypersensitivity disorders characterized by symmetric red, patchy lesions, primarily on the arms and legs. The cause is unknown, but EM frequently occurs in association with herpes simplex virus , suggesting an immunologic process initiated by the virus. In half of the cases, the triggering agents appear to be medications, including anticonvulsants, sulfonamides, nonsteroidal anti-inflammatory drugs, and other antibiotics. In addition, some cases appear to be associated with infectious organisms such as Mycoplasma pneumoniae and many viral agents. Erythema multiforme is the mildest of three skin disorders that are often discussed in relation to each other. It is generally the mildest of the three. More severe is Stevens-Johnson syndrome . The most severe of the three is toxic epidermal necrolysis (TEN).

Data source
FinnGen phenocode L12_ERYTHEMAMULTIF
Hospital Discharge registry ICD-10: L51, ICD-9: 6951A/6951C/6951B, ICD-8: 69510
Cause of Death registry ICD-10: L51, ICD-9: 6951A/6951C/6951B, ICD-8: 69510
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 0050185
GWAS catalog 1000694
MESH D004892
SNOMED CT 36715001

Key figures

Sex All Female Male
Number of individuals 193 129 64
Unadjusted prevalence (%) 0.15 0.17 0.11
Mean age at first event (years) 48.47 47.91 49.59
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 18.13 20.93 12.5
Case fatality at 5-years (%) 5.7 6.2 4.69

Associations