Skin changes due to chronic exposure to nonionizing radiation

Description

actinic keratosis: A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.

Data source
FinnGen phenocode L12_NONIONRADISKIN
Hospital Discharge registry ICD-10: L57
Cause of Death registry ICD-10: L57
Include L12_ACTINKERA, L12_ACTINRETICU, L12_CUTRHOMBNUCHA, L12_POIKOLOCIVAT, L12_CUTLAXSEN, L12_ACTINICGRAN, L12_NONIONRADISKINNAS
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 8866
GWAS catalog 0002496
MESH D055623
SNOMED CT 398838000

Key figures

Sex All Female Male
Number of individuals 2754 1541 1213
Unadjusted prevalence (%) 2.08 2.05 2.11
Mean age at first event (years) 69.93 69.09 71.01
Median number of events / individual 2 2 2

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 43.36 39.2 48.64
Case fatality at 5-years (%) 6.25 5.71 6.92

Associations