Osteoporosis

Description

osteoporosis: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).

Data source
FinnGen phenocode M13_OSTEOPOROSIS
Hospital Discharge registry ICD-10: M81/M80, ICD-8: 7230|72391
Cause of Death registry ICD-10: M81/M80, ICD-8: 7230|72391
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 11476
GWAS catalog 0003882
MESH D010024
SNOMED CT 64859006

Key figures

Sex All Female Male
Number of individuals 1898 1516 382
Unadjusted prevalence (%) 1.43 2.02 0.67
Mean age at first event (years) 66.44 67.4 62.62
Median number of events / individual 1 1 2

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 33.93 32.85 38.22
Case fatality at 5-years (%) 13.07 12.2 16.49

Associations