Sicca syndrome [Sjögren]


Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

Data source
FinnGen phenocode M13_SJOGREN
Hospital Discharge registry ICD-10: M350, ICD-8: 73490
Cause of Death registry ICD-10: M350, ICD-8: 73490
Level in the ICD-hierarchy 4
First defined in version DF2
DOID 12894, 12900
GWAS catalog 0000699
MESH D012859
SNOMED CT 83901003

Key figures

Sex All Female Male
Number of individuals 749 653 96
Unadjusted prevalence (%) 0.57 0.87 0.17
Mean age at first event (years) 54.28 53.97 56.38
Median number of events / individual 2 2 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 48.06 49.62 37.5
Case fatality at 5-years (%) 2.4 2.14 4.17