Carcinoma in situ of breast
Description
ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.
Data source
| FinnGen phenocode | CD2_INSITU_BREAST |
| Hospital Discharge registry | ICD-10: D05 |
| Cause of Death registry | ICD-10: D05 |
| Sex specific endpoint | 2 |
| Include | CD2_INSITU_BREAST_LOBULAR, CD2_INSITU_BREAST_INTRADUCTAL, CD2_INSITU_BREAST_NOS |
| Level in the ICD-hierarchy | 2 |
| First defined in version | DF2 |
Key figures
| Sex | All | Female | Male |
| Number of individuals | 600 | 596 | N/A |
| Unadjusted prevalence (%) | 0.45 | 0.79 | N/A |
| Mean age at first event (years) | 59.23 | 59.38 | N/A |
| Median number of events / individual | 2 | 2 | N/A |
Clinical metrics
| Sex | All | Female | Male |
| Recurrence within 6 months (%) | 45.83 | 45.97 | N/A |
| Case fatality at 5-years (%) | 1.67 | 1.68 | N/A |