Description
pituitary-dependent Cushing's disease: Adrenocorticotropic hormone dependent Cushing syndrome (ACTH-dependent CS) is a form of endogenous CS (see this term) caused by abnormal production of ACTH due, in 80% of cases, to ACTH oversecretion by a pituitary adenoma (Cushing disease, CD) and in 20% of cases to ectopic ACTH secretion (CS due to EAS; see these terms) by an extrapituitary tumor (in 50% of cases originating in the lungs or less commonly in the thymus, pancreas, adrenal gland or thyroid) or very rarely due to a tumor secreting both ACTH and corticotrophin-releasing hormone (CRH).
Data source
| FinnGen phenocode |
E4_ENDOGLAND |
| Include |
E4_PARATHYRO, E4_HYPERPIT, E4_HYPOPIT, E4_DIABINSIPIDUS, E4_HYPOTHALDYSF, E4_PITUDISNAS, E4_CUSHING, E4_ADRENOGEN, E4_HYPERALDO, E4_ADRENAL, E4_OVARDYS, E4_TESTIDYS, E4_DISPUB, E4_DYSPOLYGL, E4_THYMUSDIS, E4_ENDODIS |
| Level in the ICD-hierarchy |
2 |
| First defined in version |
DF2 |
Ontology