Diseases of middle ear and mastoid

Description

cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.

Data source
FinnGen phenocode H8_MIDDLEMASTOID
Hospital Discharge registry ICD-10: H72/H73/H65/H70/H69/H74/H68/H66/H71
Cause of Death registry ICD-10: H74/H70/H66/H65/H71/H73/H72/H68/H69
Include H8_NONSUPPNAS, H8_MED_SUPP, H8_OTIMEDINOTH, H8_EUSTSALP, H8_EUSTNAS, H8_MASTACU, H8_MASTCHRON, H8_PETROS, H8_MASTNAS, H8_CHOLEASTOMA, H8_PERFORATION, H8_MYRINGACU, H8_MYRINGCHRON, H8_MYRINGNAS, H8_TYMPSCLE, H8_MIDDLEADDH, H8_DISCON, H8_OSSICABN, H8_POLYPMIDD, H8_MIDDMASTNAS, H8_MIDDMASTINOTH
Level in the ICD-hierarchy 2
First defined in version DF2
Ontology
DOID 10964, 11433
GWAS catalog 1000678
MESH D018424
SNOMED CT 194339007

Key figures

Sex All Female Male
Number of individuals 6469 3611 2858
Unadjusted prevalence (%) 4.88 4.81 4.98
Mean age at first event (years) 27.36 27.95 26.62
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 25.75 25.84 25.65
Case fatality at 5-years (%) 1.34 0.97 1.82

Associations