Radiation-related disorders of the skin and subcutaneous tissue

Description

porokeratosis: a specific disorder of keratinization that is characterized histologically by the presence of a cornoid lamella, a thin column of closely stacked, parakeratotic cells extending through the stratum corneum with a thin or absent granular layer.

Data source
FinnGen phenocode L12_RADIATIONRELATEDSKIN
Hospital Discharge registry ICD-10: L55/L59/L56/L58/L57
Cause of Death registry ICD-10: L55/L58/L57/L56/L59
Include L12_SUNBURN, L12_OTHACUSKINSUN, L12_NONIONRADISKIN, L12_RADIODERMATITIS, L12_SKINRADIOTH
Level in the ICD-hierarchy 2
First defined in version DF2
Ontology
DOID 3805
GWAS catalog 1000757
SNOMED CT 400080004

Key figures

Sex All Female Male
Number of individuals 3060 1705 1355
Unadjusted prevalence (%) 2.31 2.27 2.36
Mean age at first event (years) 66.8 66.49 67.19
Median number of events / individual 2 2 2

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 40.72 37.71 44.5
Case fatality at 5-years (%) 5.65 5.16 6.27

Associations