Polyarteritis nodosa and related conditions

Description

Polyarteritis Nodosa: ['A necrotizing vasculitis that affects medium-sized arteries, it is usually idiopathic, and may be triggered by viral infections (Hepatitis B, also others). A multisystem disease, it most commonly affects skin (nodules, livedo reticularis) and peripheral nerves; higher morbidity is associated with gastrointestinal, central nervous system, cardiac, and/or other organ involvement. Anti-neutrophil cytoplasmic antibodies (ANCA) are typically negative. [ NCI ]']

Data source
FinnGen phenocode M13_POLYARTERETAL
Hospital Discharge registry ICD-10: M30
Cause of Death registry ICD-10: M30
Include M13_POLNODOSA, M13_CHURGSTRAUSS, M13_JUVEPOLYNOD, M13_KAWASAKI, M13_POYARTOTH
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 9810
GWAS catalog 0009012

Key figures

Sex All Female Male
Number of individuals 93 60 33
Unadjusted prevalence (%) 0.07 0.08 0.06
Mean age at first event (years) 53.18 52.15 55.04
Median number of events / individual 1 1 1

Clinical metrics

Sex All Female Male
Recurrence within 6 months (%) 38.71 41.67 33.33
Case fatality at 5-years (%) 11.83 8.33 18.18

Associations